Publications

Mascuch, S. J., Demko, A., Viulu, S., Ginigini, J., Soapi, K., Jensen, P., & Kubanek, J. (2022). Antibiotic activity altered by competitive interactions between two coral reef-associated bacteria. Microbial Ecology, 10. https://doi.org/10.1007/s00248-022-02016-6
Tuttle, R. N., Rouse, G. W., Castro-Falcon, G., Hughes, C. C., & Jensen, P. R. (2022). Specialized metabolite-mediated predation defense in the marine actinobacterium Salinispora. Applied and Environmental Microbiology, 88(1), 11. https://doi.org/10.1128/aem.01176-21
Castro-Falcon, G., Creamer, K. E., Chase, A. B., Kim, M. C., Sweeney, D., Glukhov, E., Fenical, W., & Jensen, P. R. (2022). Structure and candidate biosynthetic gene cluster of a manumycin-type metabolite from Salinispora pacifica. Journal of Natural Products, 85(4), 980–986. ://WOS:000791431400023
Chase, A. B., Sweeney, D., Muskat, M. N., Guillen-Matus, D. G., & Jensen, P. R. (2021). Vertical Inheritance Facilitates Interspecies Diversification in Biosynthetic Gene Clusters and Specialized Metabolites. Mbio, 12(6), 15.
Demko, A. M., Patin, N. V., & Jensen, P. R. (2021). Microbial diversity in tropical marine sediments assessed using culture-dependent and culture-independent techniques. Environmental Microbiology, 17. https://doi.org/10.1111/1462-2920.15798
Shang, Z., Ferris, Z. E., Sweeney, D., Chase, A. B., Yuan, C. H., Hui, Y., Hou, L. K., Older, E. A., Xue, D., Tang, X. Y., Zhang, W. P., Nagarkatti, P., Nagarkatti, M., Testerman, T. L., Jensen, P. R., & Li, J. (2021). Grincamycins P-T: Rearranged angucyclines from the marine sediment-derived Streptomyces sp. CNZ-748 inhibit cell lines of the rare cancer pseudomyxoma peritonei. Journal of Natural Products, 84(5), 1638–1648. https://doi.org/10.1021/acs.jnatprod.1c00179
Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., Aleti, G., Moghaddam, J. A., Aron, A. T., Aziz, S., Bauermeister, A., Bauman, K. D., Baunach, M., Beemelmanns, C., Beman, J. M., Berlanga-Clavero, M. V., Blacutt, A. A., Bode, H. B., Boullie, A., … van der Hooft, J. J. J. (2021). A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology. https://doi.org/10.1038/s41589-020-00724-z
Kudo, Y., Awakawa, T., Du, Y. L., Jordan, P. A., Creamer, K. E., Jensen, P. R., Linington, R. G., Ryan, K. S., & Moore, B. S. (2020). Expansion of gamma-butyrolactone signaling molecule biosynthesis to phosphotriester natural products. Acs Chemical Biology, 15(12), 3253–3261. https://doi.org/10.1021/acschembio.0c00824
Roman-Ponce, B., Millan-Aguinaga, N., Guillen-Matus, D., Chase, A. B., Ginigini, J. G. M., Soapi, K., Feussner, K. D., Jensen, P. R., & Trujillo, M. E. (2020). Six novel species of the obligate marine actinobacterium Salinispora, Salinispora cortesiana sp. nov., Salinispora fenicalii sp. nov., Salinispora goodfellowii sp. nov., Salinispora mooreana sp. nov., Salinispora oceanensis sp. nov. and Salinispora vitiensis sp. nov., and emended description of the genus Salinispora. International Journal of Systematic and Evolutionary Microbiology, 70(8), 4668–4682. https://doi.org/10.1099/ijsem.0.004330
Nair, V., Kim, M. C., Golen, J. A., Rheingold, A. L., Castro, G. A., Jensen, P. R., & Fenical, W. (2020). Verrucosamide, a cytotoxic 1,4-thiazepane-containing thiodepsipeptide from a marine-derived actinomycete. Marine Drugs, 18(11). https://doi.org/10.3390/md18110549
Schlawis, C., Harig, T., Ehlers, S., Guillen-Matus, D. G., Creamer, K. E., Jensen, P. R., & Schulz, S. (2020). Extending the salinilactone family. Chembiochem, 21(11), 1629–1632. https://doi.org/10.1002/cbic.201900764
Busch, J., Agarwal, V., Schorn, M., Machado, H., Moore, B. S., Rouse, G. W., Gram, L., & Jensen, P. R. (2019). Diversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas. Environmental Microbiology, 21(5), 1575–1585. https://doi.org/10.1111/1462-2920.14532
Tuttle, R. N., Demko, A. M., Patin, N. V., Kapono, C. A., Donia, M. S., Dorrestein, P., & Jensen, P. R. (2019). Detection of natural products and their producers in ocean sediments. Applied and Environmental Microbiology, 85(8). https://doi.org/10.1128/aem.02830-18
Castro-Falcon, G., Millan-Aguinaga, N., Roullier, C., Jensen, P. R., & Hughes, C. C. (2018). Nitrosopyridine probe to detect polyketide natural products with conjugated alkenes: Discovery of novodaryamide and nocarditriene. Acs Chemical Biology, 13(11), 3097–3106. https://doi.org/10.1021/acschembio.8b00598
Kim, M. C., Machado, H., Jang, K. H., Trzoss, L., Jensen, P. R., & Fenical, W. (2018). Integration of Genomic Data with NMR Analysis Enables Assignment of the Full Stereostructure of Neaumycin B, a Potent Inhibitor of Glioblastoma from a Marine-Derived Micromonospora. Journal of the American Chemical Society, 140(34), 10775–10784. https://doi.org/10.1021/jacs.8b04848
Patin, N. V., Floros, D. J., Hughes, C. C., Dorrestein, P. C., & Jensen, P. R. (2018). The role of inter-species interactions in Salinispora specialized metabolism. Microbiology-Sgm, 164(7), 946–955. https://doi.org/10.1099/mic.0.000679
Bruns, H., Crusemann, M., Letzel, A. C., Alanjary, M., McInerney, J. O., Jensen, P. R., Schulz, S., Moore, B. S., & Ziemert, N. (2018). Function-related replacement of bacterial siderophore pathways. Isme Journal, 12(2), 320–329. https://doi.org/10.1038/ismej.2017.137
Amos, G. C. A., Awakawa, T., Tuttle, R. N., Letzel, A. C., Kim, M. C., Kudo, Y., Fenical, W., Moore, B. S., & Jensen, P. R. (2017). Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality. Proceedings of the National Academy of Sciences of the United States of America, 114(52), E11121–E11130. https://doi.org/10.1073/pnas.1714381115
Machado, H., Tuttle, R. N., & Jensen, P. R. (2017). Omics-based natural product discovery and the lexicon of genome mining. Current Opinion in Microbiology, 39, 136–142. https://doi.org/10.1016/j.mib.2017.10.025
Letzel, A. C., Li, J., Amos, G. C. A., Millan-Aguinaga, N., Ginigini, J., Abdelmohsen, U. R., Gaudencio, S. P., Ziemert, N., Moore, B. S., & Jensen, P. R. (2017). Genomic insights into specialized metabolism in the marine actinomycete Salinispora. Environmental Microbiology, 19(9), 3660–3673. https://doi.org/10.1111/1462-2920.13867
Millan-Aguinaga, N., Chavarria, K. L., Ugalde, J. A., Letzel, A. C., Rouse, G. W., & Jensen, P. R. (2017). Phylogenomic Insight into Salinispora (Bacteria, Actinobacteria) Species Designations. Scientific Reports, 7. https://doi.org/10.1038/s41598-017-02845-3
Gallagher, K. A., Wanger, G., Henderson, J., Llorente, M., Hughes, C. C., & Jensen, P. R. (2017). Ecological implications of hypoxia-triggered shifts in secondary metabolism. Environmental Microbiology, 19(6), 2182–2191. https://doi.org/10.1111/1462-2920.13700
Asolkar, R. N., Singh, A., Jensen, P. R., Aalbersberg, W., Carte, B. K., Feussner, K. D., Subramani, R., DiPasquale, A., Rheingold, A. L., & Fenical, W. (2017). Marinocyanins, cytotoxic bromo-phenazinone meroterpenoids from a marine bacterium from the streptomycete Glade MAR4. Tetrahedron, 73(16), 2234–2241. https://doi.org/10.1016/j.tet.2017.03.003
Agarwal, V., Blanton, J. M., Podell, S., Taton, A., Schorn, M. A., Busch, J., Lin, Z., Schmidt, E. W., Jensen, P. R., Paul, V. J., Biggs, J. S., Golden, J. W., Allen, E. E., & Moore, B. S. (2017). Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges. Nat Chem Biol, advance online publication. https://doi.org/10.1038/nchembio.2330
Crusemann, M., O’Neill, E. C., Larson, C. B., Melnik, A. V., Floros, D. J., da Silva, R. R., Jensen, P. R., Dorrestein, P. C., & Moore, B. S. (2017). Prioritizing natural product diversity in a collection of 146 bacterial strains based on growth and extraction protocols. Journal of Natural Products, 80(3), 588–597. https://doi.org/10.1021/acsjnatprod.6b00722
Patin, N. V., Schorn, M., Aguinaldo, K., Lincecum, T., Moore, B. S., & Jensen, P. R. (2017). Effects of actinomycete secondary metabolites on sediment microbial communities. Applied and Environmental Microbiology, 83(4). https://doi.org/10.1128/aem.02676-16
Schorn, M. A., Alanjary, M. M., Aguinaldo, K., Korobeynikov, A., Podell, S., Patin, N., Lincecum, T., Jensen, P. R., Ziemert, N., & Moore, B. S. (2016). Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters. Microbiology-Sgm, 162(12), 2075–2086. https://doi.org/10.1099/mic.0.000386
Jensen, P. R. (2016). Natural products and the gene cluster revolution. Trends in Microbiology, 24(12), 968–977. https://doi.org/10.1016/j.tim.2016.07.006
Floros, D. J., Jensen, P. R., Dorrestein, P. C., & Koyama, N. (2016). A metabolomics guided exploration of marine natural product chemical space. Metabolomics, 12(9). https://doi.org/10.1007/s11306-016-1087-5
Wang, M. X., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N., Peng, Y., Nguyen, D. D., Watrous, J., Kapono, C. A., Luzzatto-Knaan, T., Porto, C., Bouslimani, A., Melnik, A. V., Meehan, M. J., Liu, W. T., Criisemann, M., Boudreau, P. D., Esquenazi, E., Sandoval-Calderon, M., … Bandeira, N. (2016). Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology, 34(8), 828–837. https://doi.org/10.1038/nbt.3597
Patin, N. V., Duncan, K. R., Dorrestein, P. C., & Jensen, P. R. (2016). Competitive strategies differentiate closely related species of marine actinobacteria. Isme Journal, 10(2), 478–490. https://doi.org/10.1038/ismej.2015.128
Tang, X. Y., Li, J., Millan-Aguinaga, N., Zhang, J. J., O’Neill, E. C., Ugalde, J. A., Jensen, P. R., Mantovani, S. M., & Moore, B. S. (2015). Identification of thiotetronic acid antibiotic biosynthetic pathways by target-directed genome mining. Acs Chemical Biology, 10(12), 2841–2849. https://doi.org/10.1021/acschembio.5b00658
Ruckert, C., Leipoldt, F., Zeyhle, P., Fenical, W., Jensen, P. R., Kalinowski, J., Heide, L., & Kaysser, L. (2015). Complete genome sequence of Streptomyces sp CNQ-509, a prolific producer of meroterpenoid chemistry. Journal of Biotechnology, 216, 140–141. https://doi.org/10.1016/j.jbiotec.2015.08.009
Gallagher, K. A., & Jensen, P. R. (2015). Genomic insights into the evolution of hybrid isoprenoid biosynthetic gene clusters in the MAR4 marine streptomycete clade. Bmc Genomics, 16. https://doi.org/10.1186/s12864-015-2110-3
Choi, E. J., Nam, S. J., Paul, L., Beatty, D., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2015). Previously uncultured marine bacteria linked to novel alkaloid production. Chemistry & Biology, 22(9), 1270–1279. https://doi.org/10.1016/j.chembiol.2015.07.014
Nam, S. J., Kauffman, C. A., Jensen, P. R., Moore, C. E., Rheingold, A. L., & Fenical, W. (2015). Actinobenzoquinoline and actinophenanthrolines a-c, unprecedented alkaloids from a marine actinobacterium. Organic Letters, 17(13), 3240–3243. https://doi.org/10.1021/acs.orglett.5b01387
Duncan, K. R., Crusemann, M., Lechner, A., Sarkar, A., Li, J., Ziemert, N., Wang, M. X., Bandeira, N., Moore, B. S., Dorrestein, P. C., & Jensen, P. R. (2015). Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. Chemistry & Biology, 22(4), 460–471. https://doi.org/10.1016/j.chembiol.2015.03.010
Wietz, M., Millan-Aguinaga, N., & Jensen, P. R. (2014). CRISPR-Cas systems in the marine actinomycete Salinispora: linkages with phage defense, microdiversity and biogeography. Bmc Genomics, 15. https://doi.org/10.1186/1471-2164-15-936
Ziemert, N., Lechner, A., Wietz, M., Millan-Aguinaga, N., Chavarria, K. L., & Jensen, P. R. (2014). Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora. Proceedings of the National Academy of Sciences of the United States of America, 111(12), E1130–E1139. https://doi.org/10.1073/pnas.1324161111
Jensen, P. R., Chavarria, K. L., Fenical, W., Moore, B. S., & Ziemert, N. (2014). Challenges and triumphs to genomics-based natural product discovery. Journal of Industrial Microbiology & Biotechnology, 41(2), 203–209. https://doi.org/10.1007/s10295-013-1353-8
Farnaes, L., Coufal, N. G., Kauffman, C. A., Rheingold, A. L., DiPasquale, A. G., Jensen, P. R., & Fenical, W. (2014). Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis. Journal of Natural Products, 77(1), 15–21. https://doi.org/10.1021/np400466j
Gallagher, K. A., Rauscher, K., Ioca, L. P., & Jensen, P. R. (2013). Phylogenetic and chemical diversity of a hybrid-isoprenoid producing streptomycete lineage. Applied and Environmental Microbiology, 79(22), 6894–6902. https://doi.org/10.1128/aem.01814-13
Nam, S. J., Kauffman, C. A., Paul, L. A., Jensen, P. R., & Fenical, W. (2013). Actinoranone, a cytotoxic meroterpenoid of unprecedented structure from a marine adapted streptomyces sp. Organic Letters, 15(21), 5400–5403. https://doi.org/10.1021/ol402080s
Freel, K. C., Millan-Aguinaga, N., & Jensen, P. R. (2013). Multilocus sequence typing reveals evidence of homologous recombination linked to antibiotic resistance in the genus salinispora. Applied and Environmental Microbiology, 79(19), 5997–6005. https://doi.org/10.1128/aem.00880-13
Ilan, E. Z., Torres, M. R., Prudhomme, J., Le Roch, K., Jensen, P. R., & Fenical, W. (2013). Farnesides A and B, sesquiterpenoid nucleoside ethers from a marine-derived Streptomyces sp., strain CNT-372 from Fiji. Journal of Natural Products, 76(9), 1815–1818. https://doi.org/10.1021/np400351t
Wietz, M., Duncan, K., Patin, N. V., & Jensen, P. R. (2013). Antagonistic interactions mediated by marine bacteria: The role of small molecules. Journal of Chemical Ecology, 39(7), 879–891. https://doi.org/10.1007/s10886-013-0316-x
Prieto-Davo, A., Villarreal-Gomez, L. J., Forschner-Dancause, S., Bull, A. T., Stach, J. E. M., Smith, D. C., Rowley, D. C., & Jensen, P. R. (2013). Targeted search for actinomycetes from nearshore and deep-sea marine sediments. Fems Microbiology Ecology, 84(3), 510–518. https://doi.org/10.1111/1574-6941.12082
Cheng, Y. B., Jensen, P. R., & Fenical, W. (2013). Cytotoxic and antimicrobial napyradiomycins from two marine-derived streptomyces strains. European Journal of Organic Chemistry, 18, 3751–3757. https://doi.org/10.1002/ejoc.201300349
Ahmed, L., Jensen, P. R., Freel, K. C., Brown, R., Jones, A. L., Kim, B. Y., & Goodfellow, M. (2013). Salinispora pacifica sp nov., an actinomycete from marine sediments. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology, 103(5), 1069–1078. https://doi.org/10.1007/s10482-013-9886-4
Choi, E. J., Beatty, D. S., Paul, L. A., Fenical, W., & Jensen, P. R. (2013). Mooreia alkaloidigena gen. nov., sp nov and Catalinimonas alkaloidigena gen. nov., sp nov., alkaloid-producing marine bacteria in the proposed families Mooreiaceae fam. nov and Catalimonadaceae fam. nov in the phylum Bacteroidetes. International Journal of Systematic and Evolutionary Microbiology, 63, 1219–1228. https://doi.org/10.1099/ijs.0.043752-0